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Thorne

Methyl-Guard Plus®

Methyl-Guard Plus provides superior methyl donors – trimethylglycine, 5-MTHF, and methylcobalamin – combined with bioactive vitamins B2 and B6 in a powerhouse formula for whole-body methylation support.

$49.60$62.00save $12.40
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On orders over $150
Practitioner grade
Direct from the manufacturer
Member pricing
Up to 20% under retail

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Product insights

  • Methyl-Guard Plus provides a comprehensive blend of methyl donors, including trimethylglycine (TMG), 5-MTHF (active folate), and methylcobalamin (active B12), crucial for optimal methylation processes throughout the body.
  • The formula incorporates bioactive forms of vitamins B2 (Riboflavin 5'-Phosphate) and B6 (Pyridoxal 5'-Phosphate), ensuring efficient utilization in metabolic pathways and supporting overall cellular function.
  • Betaine anhydrous (Trimethylglycine) supports healthy homocysteine metabolism, which is important for cardiovascular and neurological health.
  • 5-MTHF bypasses the MTHFR enzyme, making folate readily available for individuals with MTHFR gene variations, supporting healthy methylation even in those with genetic predispositions.

Suggested use

From the manufacturer
Take 1-3 capsules daily or as recommended by a health-care practioner.

What it supports

6 benefits
  • Supports healthy methylation pathways in the body
  • Helps maintain healthy homocysteine levels
  • Promotes cardiovascular and cognitive wellness
  • Supports neurotransmitter production for mood balance
  • Promotes efficient liver detoxification processes
  • Enhances cellular energy production

What's in it

Per serving
Ingredient
Amount
% Daily Value
Riboflavin (as Riboflavin 5'-Phosphate Sodium)
90 mg
**
Vitamin B6 (as Pyridoxal 5'-Phosphate)
45 mg
**
Folate (3 mg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)
5 mg DFE
**
Vitamin B12 (as Methylcobalamin)
3 mg
**
Betaine Anhydrous (Trimethylglycine)
1.8 g
**
Other ingredients: Hypromellose (derived from cellulose) capsule, Calcium Citrate, Calcium Laurate.
** Daily Value not established.

The research

3 cited studies
1.
Homocysteine and Cardiovascular Health

Research indicates that maintaining healthy homocysteine levels through adequate intake of folate, B12, and betaine supports cardiovascular health.

2.
MTHFR Polymorphisms and Folate

Studies show that 5-MTHF is a more bioavailable form of folate for individuals with MTHFR gene variations, supporting optimal methylation.

3.
Betaine and Liver Health

Betaine (Trimethylglycine) has been shown to support healthy liver function and lipid metabolism.