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  3. Bone & Musculoskeletal Health
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  5. BRF 45™

Designs for Health

BRF 45™

BRF 45™ promotes bone health and arterial health with a high-dose of vitamin K2 (as MK-4) and supporting nutrients.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

  • BRF 45™ features 45 mg of vitamin K2 (as MK-4), a clinically studied amount shown to positively impact bone remodeling and arterial health.
  • Vitamin K2 (as MK-4) plays a crucial role in activating proteins that regulate calcium deposition, ensuring calcium is directed to the bones and teeth rather than soft tissues.
  • The inclusion of vitamins K1 and geranylgeraniol supports the body's natural conversion to vitamin K2 (as MK-4), optimizing its bioavailability and utilization.
  • This comprehensive formula provides nutritional support for individuals at risk of bone loss or arterial stiffness, particularly during periods of hormonal change.
  • Promotes healthy bone strength and density
  • Supports arterial health and elasticity
  • Helps maintain healthy calcium utilization
  • Supports bone remodeling processes
  • May support healthy bone metabolism
  • Vitamin K (as Vitamin K1 Phytonadione)1000 mcg
  • Vitamin K2 (as Menaquinone-4)45 mg
  • Trans-Geranylgeraniol (GG-Gold®) [from annatto (Bixa orellana)(seed)]30 mg

Other Ingredients: Medium chain triglycerides, bovine gelatin, glycerine, purified water.

Take 2 softgels per day with meals, or as directed by your health-care practitioner (divided dosing recommended).

  • Vitamin K2 and Bone Health

    Studies suggest vitamin K2, particularly MK-4, plays a significant role in bone metabolism by activating osteocalcin, a protein essential for incorporating calcium into bone.

  • Vitamin K2 and Arterial Health

    Research indicates that vitamin K2 may help inhibit arterial calcification by activating matrix Gla protein (MGP), a protein that prevents calcium deposition in arteries.