Oxaloacetate

By going through RTHM, you save $100 per bottle of 90 capsules of Oxaloacetate 500mg.

FatiguePost-Exertional MalaiseBrain FogNeuroinflammation

Your status

Start a short safety assessment to request this.

Get started→

Pricing example

RTHM Safety Assessment

Only charged if approved

Pharmacy Cost

90-day supply + shipping

$399

Total for 90 days

With RTHM discount

$399

RTHM Safety Assessment Fee

Paid to RTHM. Every 90 days, only if approved.

Pharmacy cost

90-day fill + shipping

$399

Estimated total for 90 days

With RTHM discount

$399

Key benefits

3 highlights

01
Reduce Mental Fatigue
A randomized placebo-controlled study showed that ME/CFS patients taking oxaloacetate experienced a >25% reduction in fatigue, with 40% of participants being “super responders” showing fatigue reductions up to 63%.
02
Boost Energy Levels
In an open-label study, oxaloacetate reduced mental and physical fatigue by up to 33% in ME/CFS patients and up to 46.8% in Long COVID patients over six weeks.
03
Enhance Overall Health
Oxaloacetate improves mitochondrial energy production, regulates blood glucose, and exhibits anti-cancer properties, supporting metabolic health and overall well-being.

Is Oxaloacetate right for me?

5 questions

Oxaloacetate may help with:

Fatigue and low energy
Brain fog
Post-exertional malaise (PEM)
Exercise intolerance
Neuroinflammation

Patients with ME/CFS, Long COVID, or other conditions linked to mitochondrial dysfunction may benefit from oxaloacetate.

Research & evidence

3 studies

Study #1: Oxaloacetate Reduces Fatigue by Over 25% in ME/CFS Patients

A preliminary 2024 randomized placebo-controlled study in ME/CFS patients found a statistically significant >25% average reduction in fatigue in those taking oxaloacetate, compared to a non-significant ~10% reduction in the placebo group. Additionally, 40% of participants were “super responders,” experiencing an average fatigue reduction of 63%.

RESTORE ME: A RCT of Oxaloacetate for Improving Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

View Study

Study #2: Oxaloacetate May Reduce Fatigue by over 46.8% in Long COVID patients

An open-label study found oxaloacetate reduced mental and physical fatigue by up to 33% in ME/CFS patients and 46.8% in Long COVID patients over six weeks. Fatigue improvements were dose-dependent in ME/CFS patients.

Oxaloacetate Treatment for Fatigue in ME/CFS and Long COVID: A Non-Randomized Clinical Trial

View Study

Study #3: Natural Oxaloacetate Levels Are Significantly Lower in ME/CFS Patients

A Cornell study found significantly lower oxaloacetate levels in ME/CFS patients compared to healthy controls. This supports the role of oxaloacetate supplementation in improving mitochondrial energy production.

Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Not Due to Anti-mitochondrial Antibodies

View Study

What people are saying about their experience with Oxaloacetate

3 excerpts

It’s helped me. But I do build up a tolerance sometimes. Some people use it only for crashes. It can really help but it’s not a fix.

ANDHarrisonreddit.com

It helps me so much. Like, so much. I take the benagene for mecfs and take 1000mgs a day. I’ve noticed that it makes my energy envelope a little bit more stretchy, like I can push a little bit and be okay. I’ve been pacing religiously but it seems oxoloacetate increases the gains made from pacing, p…

Thesaltpacketreddit.com

It has helped me! I’ve taken it for over 3 months at the recommended dose. When I had tried it at a lower dosage it did nothing. I’ve been able to stop using my wheelchair. I’ve been able to visit with friends. It’s the only thing that has helped me. The cost is immense. I’m fortunate to have the re…

ANDHarrisonreddit.com

Oxaloacetate

By going through RTHM, you save $100 per bottle of 90 capsules of Oxaloacetate 500mg.

FatiguePost-Exertional MalaiseBrain FogNeuroinflammation

Your status

Start a short safety assessment to request this.

Get started→

Pricing example

RTHM Safety Assessment

Only charged if approved

Pharmacy Cost

90-day supply + shipping

$399

Total for 90 days

With RTHM discount

$399

RTHM Safety Assessment Fee

Paid to RTHM. Every 90 days, only if approved.

Pharmacy cost

90-day fill + shipping

$399

Estimated total for 90 days

With RTHM discount

$399

Key benefits

3 highlights

01
Reduce Mental Fatigue
A randomized placebo-controlled study showed that ME/CFS patients taking oxaloacetate experienced a >25% reduction in fatigue, with 40% of participants being “super responders” showing fatigue reductions up to 63%.
02
Boost Energy Levels
In an open-label study, oxaloacetate reduced mental and physical fatigue by up to 33% in ME/CFS patients and up to 46.8% in Long COVID patients over six weeks.
03
Enhance Overall Health
Oxaloacetate improves mitochondrial energy production, regulates blood glucose, and exhibits anti-cancer properties, supporting metabolic health and overall well-being.

Is Oxaloacetate right for me?

5 questions

Oxaloacetate may help with:

Fatigue and low energy
Brain fog
Post-exertional malaise (PEM)
Exercise intolerance
Neuroinflammation

Patients with ME/CFS, Long COVID, or other conditions linked to mitochondrial dysfunction may benefit from oxaloacetate.

Research & evidence

3 studies

Study #1: Oxaloacetate Reduces Fatigue by Over 25% in ME/CFS Patients

RESTORE ME: A RCT of Oxaloacetate for Improving Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

View Study

Study #2: Oxaloacetate May Reduce Fatigue by over 46.8% in Long COVID patients

Oxaloacetate Treatment for Fatigue in ME/CFS and Long COVID: A Non-Randomized Clinical Trial

View Study

Study #3: Natural Oxaloacetate Levels Are Significantly Lower in ME/CFS Patients

Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Not Due to Anti-mitochondrial Antibodies

View Study

What people are saying about their experience with Oxaloacetate

3 excerpts

It’s helped me. But I do build up a tolerance sometimes. Some people use it only for crashes. It can really help but it’s not a fix.

ANDHarrisonreddit.com

Thesaltpacketreddit.com

ANDHarrisonreddit.com

Oxaloacetate

RTHM Safety Assessment

Pharmacy Cost

Total for 90 days

Key benefits

Reduce Mental Fatigue

Boost Energy Levels

Enhance Overall Health

Is Oxaloacetate right for me?

Research & evidence

Study #1: Oxaloacetate Reduces Fatigue by Over 25% in ME/CFS Patients

Study #2: Oxaloacetate May Reduce Fatigue by over 46.8% in Long COVID patients

Study #3: Natural Oxaloacetate Levels Are Significantly Lower in ME/CFS Patients

What people are saying about their experience with Oxaloacetate

Oxaloacetate

RTHM Safety Assessment

Pharmacy Cost

Total for 90 days

Key benefits

Reduce Mental Fatigue

Boost Energy Levels

Enhance Overall Health

Is Oxaloacetate right for me?

Research & evidence

Study #1: Oxaloacetate Reduces Fatigue by Over 25% in ME/CFS Patients

Study #2: Oxaloacetate May Reduce Fatigue by over 46.8% in Long COVID patients

Study #3: Natural Oxaloacetate Levels Are Significantly Lower in ME/CFS Patients

What people are saying about their experience with Oxaloacetate