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Oxaloacetate

Oxaloacetate

By going through RTHM, you save $100 per bottle of 90 capsules of Oxaloacetate 500mg.

FatiguePost-Exertional MalaiseBrain FogNeuroinflammation
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Pricing Example

RTHM Safety Assessment

Only charged if approved

$0

Pharmacy Cost

90-day supply + shipping

$399

Total for 90 days

With RTHM discount

$399

RTHM Safety
Assessment Fee

Paid every 90 days
(only charged if approved)

$0

Pharmacy
Cost

90-day supply + shipping, paid to the pharmacy

$399

Estimated total
for 90 days

With RTHM discount

$399

Reduce Mental Fatigue

A randomized placebo-controlled study showed that ME/CFS patients taking oxaloacetate experienced a >25% reduction in fatigue, with 40% of participants being “super responders” showing fatigue reductions up to 63%.

Boost Energy Levels

In an open-label study, oxaloacetate reduced mental and physical fatigue by up to 33% in ME/CFS patients and up to 46.8% in Long COVID patients over six weeks.

Enhance Overall Health

Oxaloacetate improves mitochondrial energy production, regulates blood glucose, and exhibits anti-cancer properties, supporting metabolic health and overall well-being.

Is Oxaloacetate right for me?

Oxaloacetate may help with:

  • Fatigue and low energy
  • Brain fog
  • Post-exertional malaise (PEM)
  • Exercise intolerance
  • Neuroinflammation

Patients with ME/CFS, Long COVID, or other conditions linked to mitochondrial dysfunction may benefit from oxaloacetate.

Oxaloacetate has been well-tolerated in clinical trials, with minimal side effects, including:

  • Stomach upset (improved by taking with food)
  • Headaches
  • Constipation
  • Insomnia

You should not take oxaloacetate if you:

  • Have Parkinson's disease
  • Are pregnant or breastfeeding
  • Have kidney failure

Oxaloacetate is a naturally occurring metabolite that plays a critical role in energy production within the mitochondria (the "powerhouses" of our cells). In people with ME/CFS and Long COVID, mitochondrial dysfunction can lead to severe fatigue. Oxaloacetate works by:

  • Restoring Deficient Levels: It replenishes oxaloacetate levels to support mitochondrial function.
  • Bypassing Mitochondrial Blocks: Helps the body bypass blocked energy production pathways like those seen in ME/CFS.
  • Inhibiting Lactate Production: Reduces excessive lactate generation associated with mitochondrial dysfunction.

These mechanisms help reduce physical and mental fatigue, brain fog, and post-exertional malaise.

We have designed an online assessment for oxaloacetate to ensure patient safety.

The online assessment for oxaloacetate is free. After filling out the online assessment, a clinician will review the patient's information, approve if appropriate, and provide the discount code together with instructions on how to purchase and how to titrate this medical food appropriately.

Finding the optimal dose for you is dependent on your diagnosis (ME/CFS vs. Long COVID) and how you are responding to the treatment in the first few weeks. Your optimal dose will dictate the length of time a 90 capsule bottle will last.

For example, the base dose for Long COVID is one 500mg capsule twice a day. So in this instance, a bottle of 90 capsules should last 45 days.

Learn More About Oxaloacetate on Oxaloacetate CFS

Research Studies

A preliminary 2024 randomized placebo-controlled study in ME/CFS patients found a statistically significant >25% average reduction in fatigue in those taking oxaloacetate, compared to a non-significant ~10% reduction in the placebo group. Additionally, 40% of participants were “super responders,” experiencing an average fatigue reduction of 63%.

"RESTORE ME: A RCT of Oxaloacetate for Improving Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)"

View Study

An open-label study found oxaloacetate reduced mental and physical fatigue by up to 33% in ME/CFS patients and 46.8% in Long COVID patients over six weeks. Fatigue improvements were dose-dependent in ME/CFS patients.

"Oxaloacetate Treatment for Fatigue in ME/CFS and Long COVID: A Non-Randomized Clinical Trial"

View Study

A Cornell study found significantly lower oxaloacetate levels in ME/CFS patients compared to healthy controls. This supports the role of oxaloacetate supplementation in improving mitochondrial energy production.

"Metabolic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Not Due to Anti-mitochondrial Antibodies"

View Study

What People Are Saying About Their Experience with Oxaloacetate

"It’s helped me. But I do build up a tolerance sometimes. Some people use it only for crashes. It can really help but it’s not a fix."

ANDHarrisonreddit.com

"It helps me so much. Like, so much. I take the benagene for mecfs and take 1000mgs a day. I’ve noticed that it makes my energy envelope a little bit more stretchy, like I can push a little bit and be okay. I’ve been pacing religiously but it seems oxoloacetate increases the gains made from pacing, p..."

Thesaltpacketreddit.com

"It has helped me! I’ve taken it for over 3 months at the recommended dose. When I had tried it at a lower dosage it did nothing. I’ve been able to stop using my wheelchair. I’ve been able to visit with friends. It’s the only thing that has helped me. The cost is immense. I’m fortunate to have the re..."

ANDHarrisonreddit.com