Midodrine

Get clinician-approved Midodrine for orthostatic hypotension and POTS.

ME/CFSLong COVIDPOTSOrthostatic IntoleranceDizziness

Your status

Start a short safety assessment to request this.

Get started→

Pricing example

RTHM Safety Assessment

Only charged if approved

$59

Pharmacy Cost

90-day supply + shipping

$50

Total for 90 days

With RTHM discount

$109

RTHM Safety Assessment Fee

Paid to RTHM. Every 90 days, only if approved.

$59

Pharmacy cost

90-day fill + shipping

$50

Estimated total for 90 days

With RTHM discount

$109

Key benefits

3 highlights

01
Blood Pressure Regulation
Midodrine increases blood pressure, helping to eliminate significant drops when standing and providing relief from orthostatic hypotension.
02
Physical Stability
By stabilizing blood pressure, midodrine reduces dizziness and lightheadedness, offering improved physical stability for those with autonomic dysfunction.
03
Reduced Fainting Risk
Stabilized blood pressure decreases the risk of fainting and improves confidence in daily activities.

Is Midodrine right for me?

2 questions

Midodrine is particularly effective for:

Dizziness and lightheadedness
Fainting or near-fainting spells
Blurred vision
Weakness and fatigue
Nausea

Patients with Long COVID, ME/CFS, and dysautonomia experiencing these symptoms may benefit from midodrine.

Research & evidence

4 studies

Study #1: Midodrine Effectively Relieves Orthostatic Hypotension Symptoms

A study conducted across 25 centers with 171 patients assessed the efficacy of 10 mg of midodrine taken three times daily for neurogenic orthostatic hypotension. This randomized, placebo-controlled trial showed significant improvements in standing systolic blood pressure and lightheadedness. Main adverse effects included pilomotor reactions, urinary retention, and supine hypertension.

Efficacy of Midodrine vs Placebo in Neurogenic Orthostatic Hypotension: A Randomized, Double-blind Multicenter Study

View Study

Study #2: Midodrine is Effective in Preventing Vasovagal Symptoms and Fainting

This systematic review concluded that midodrine is effective in preventing vasovagal symptoms and preventing fainting induced by head-up-tilt testing.

Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis

View Study

Study #3: Midodrine Taken Daily Improves Dizziness, Weakness, and Fatigue

This double-blind, placebo-controlled study evaluated midodrine's efficacy in 97 patients over four weeks. Participants who took midodrine (2.5, 5, or 10 mg) three times daily experienced significantly improved dizziness, weakness, and fatigue, with a notable increase in standing systolic blood pressure.

Neurogenic Orthostatic Hypotension: A Double-blind, Placebo-controlled Study with Midodrine

View Study

Study #4: Midodrine shown to improve blood pressure in POTS patients

A cross-over study of 20 patients aged 12–20 years with neuropathic and hyperadrenergic POTS showed that midodrine improved postural tachycardia in hyperadrenergic POTS. The effect was smaller in patients with neuropathic POTS. While effective, 40% of patients stopped treatment due to side effects.

Treatment of Orthostatic Intolerance with Midodrine: A Double-blind, Randomized, Cross-over Study

View Study

What people are saying about their experience with Midodrine

3 excerpts

My heart rate and fatigue were both improved. These medications have been helpful in that I can go out of the house again. I can manage the side effects.

Cindie S.stuffthatworks.health

After 2 yrs of suffering was prescribed midodrine & within 45 minutes of my first dose it was like a light was flicked on - my chest pain disappeared & had energy for the first time in 2 yrs.

u/torivettereddit.com

After seeing a cardiologist my racing heart was treated with cardizem and midodrine. This made a difference in my ability to exercise and exert myself.

Cheryl B.stuffthatworks.health

Midodrine

Get clinician-approved Midodrine for orthostatic hypotension and POTS.

ME/CFSLong COVIDPOTSOrthostatic IntoleranceDizziness

Your status

Start a short safety assessment to request this.

Get started→

Pricing example

RTHM Safety Assessment

Only charged if approved

$59

Pharmacy Cost

90-day supply + shipping

$50

Total for 90 days

With RTHM discount

$109

RTHM Safety Assessment Fee

Paid to RTHM. Every 90 days, only if approved.

$59

Pharmacy cost

90-day fill + shipping

$50

Estimated total for 90 days

With RTHM discount

$109

Key benefits

3 highlights

01
Blood Pressure Regulation
Midodrine increases blood pressure, helping to eliminate significant drops when standing and providing relief from orthostatic hypotension.
02
Physical Stability
By stabilizing blood pressure, midodrine reduces dizziness and lightheadedness, offering improved physical stability for those with autonomic dysfunction.
03
Reduced Fainting Risk
Stabilized blood pressure decreases the risk of fainting and improves confidence in daily activities.

Is Midodrine right for me?

2 questions

Midodrine is particularly effective for:

Dizziness and lightheadedness
Fainting or near-fainting spells
Blurred vision
Weakness and fatigue
Nausea

Patients with Long COVID, ME/CFS, and dysautonomia experiencing these symptoms may benefit from midodrine.

Research & evidence

4 studies

Study #1: Midodrine Effectively Relieves Orthostatic Hypotension Symptoms

Efficacy of Midodrine vs Placebo in Neurogenic Orthostatic Hypotension: A Randomized, Double-blind Multicenter Study

View Study

Study #2: Midodrine is Effective in Preventing Vasovagal Symptoms and Fainting

This systematic review concluded that midodrine is effective in preventing vasovagal symptoms and preventing fainting induced by head-up-tilt testing.

Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis

View Study

Study #3: Midodrine Taken Daily Improves Dizziness, Weakness, and Fatigue

Neurogenic Orthostatic Hypotension: A Double-blind, Placebo-controlled Study with Midodrine

View Study

Study #4: Midodrine shown to improve blood pressure in POTS patients

Treatment of Orthostatic Intolerance with Midodrine: A Double-blind, Randomized, Cross-over Study

View Study

What people are saying about their experience with Midodrine

3 excerpts

My heart rate and fatigue were both improved. These medications have been helpful in that I can go out of the house again. I can manage the side effects.

Cindie S.stuffthatworks.health

After 2 yrs of suffering was prescribed midodrine & within 45 minutes of my first dose it was like a light was flicked on - my chest pain disappeared & had energy for the first time in 2 yrs.

u/torivettereddit.com

After seeing a cardiologist my racing heart was treated with cardizem and midodrine. This made a difference in my ability to exercise and exert myself.

Cheryl B.stuffthatworks.health

Midodrine

RTHM Safety Assessment

Pharmacy Cost

Total for 90 days

Key benefits

Blood Pressure Regulation

Physical Stability

Reduced Fainting Risk

Is Midodrine right for me?

Research & evidence

Study #1: Midodrine Effectively Relieves Orthostatic Hypotension Symptoms

Study #2: Midodrine is Effective in Preventing Vasovagal Symptoms and Fainting

Study #3: Midodrine Taken Daily Improves Dizziness, Weakness, and Fatigue

Study #4: Midodrine shown to improve blood pressure in POTS patients

What people are saying about their experience with Midodrine

Midodrine

RTHM Safety Assessment

Pharmacy Cost

Total for 90 days

Key benefits

Blood Pressure Regulation

Physical Stability

Reduced Fainting Risk

Is Midodrine right for me?

Research & evidence

Study #1: Midodrine Effectively Relieves Orthostatic Hypotension Symptoms

Study #2: Midodrine is Effective in Preventing Vasovagal Symptoms and Fainting

Study #3: Midodrine Taken Daily Improves Dizziness, Weakness, and Fatigue

Study #4: Midodrine shown to improve blood pressure in POTS patients

What people are saying about their experience with Midodrine