Midodrine
Get clinician-approved Midodrine for orthostatic hypotension and POTS.
ME/CFSLong COVIDPOTS
Orthostatic IntoleranceDizziness
Pricing Example
RTHM Safety Assessment
Only charged if approved
Pharmacy Cost
90-day supply + shipping
Total for 90 days
With RTHM discount
RTHM Safety
Assessment Fee
Paid every 90 days
(only charged if approved)
$59
Pharmacy
Cost
90-day supply + shipping, paid to the pharmacy
$50
Estimated total
for 90 days
With RTHM discount
$109
Blood Pressure Regulation
Midodrine increases blood pressure, helping to eliminate significant drops when standing and providing relief from orthostatic hypotension.
Physical Stability
By stabilizing blood pressure, midodrine reduces dizziness and lightheadedness, offering improved physical stability for those with autonomic dysfunction.
Reduced Fainting Risk
Stabilized blood pressure decreases the risk of fainting and improves confidence in daily activities.
Is Midodrine right for me?
Midodrine is particularly effective for:
- Dizziness and lightheadedness
- Fainting or near-fainting spells
- Blurred vision
- Weakness and fatigue
- Nausea
Patients with Long COVID, ME/CFS, and dysautonomia experiencing these symptoms may benefit from midodrine.
Midodrine has a well-established safety profile and was even FDA approved for treating orthostatic hypotension. Common side effects include:
- Scalp tingling
- Goosebumps
- Urinary retention
- Gastrointestinal discomfort
It's important to use midodrine cautiously, especially in patients with supine hypertension, as it can further increase blood pressure when lying down.
Research Studies
A study conducted across 25 centers with 171 patients assessed the efficacy of 10 mg of midodrine taken three times daily for neurogenic orthostatic hypotension. This randomized, placebo-controlled trial showed significant improvements in standing systolic blood pressure and lightheadedness. Main adverse effects included pilomotor reactions, urinary retention, and supine hypertension.
"Efficacy of Midodrine vs Placebo in Neurogenic Orthostatic Hypotension: A Randomized, Double-blind Multicenter Study"
View StudyThis systematic review concluded that midodrine is effective in preventing vasovagal symptoms and preventing fainting induced by head-up-tilt testing.
"Midodrine for the prevention of vasovagal syncope: a systematic review and meta-analysis"
View StudyThis double-blind, placebo-controlled study evaluated midodrine's efficacy in 97 patients over four weeks. Participants who took midodrine (2.5, 5, or 10 mg) three times daily experienced significantly improved dizziness, weakness, and fatigue, with a notable increase in standing systolic blood pressure.
"Neurogenic Orthostatic Hypotension: A Double-blind, Placebo-controlled Study with Midodrine"
View StudyA cross-over study of 20 patients aged 12–20 years with neuropathic and hyperadrenergic POTS showed that midodrine improved postural tachycardia in hyperadrenergic POTS. The effect was smaller in patients with neuropathic POTS. While effective, 40% of patients stopped treatment due to side effects.
"Treatment of Orthostatic Intolerance with Midodrine: A Double-blind, Randomized, Cross-over Study"
View StudyWhat People Are Saying About Their Experience with Midodrine
"My heart rate and fatigue were both improved. These medications have been helpful in that I can go out of the house again. I can manage the side effects."
Cindie S.stuffthatworks.health
"After 2 yrs of suffering was prescribed midodrine & within 45 minutes of my first dose it was like a light was flicked on - my chest pain disappeared & had energy for the first time in 2 yrs."
u/torivettereddit.com
"After seeing a cardiologist my racing heart was treated with cardizem and midodrine. This made a difference in my ability to exercise and exert myself."
Cheryl B.stuffthatworks.health