Low Dose Naltrexone
Get a safe and clinician approved prescription for LDN.
ME/CFSLong COVID
HeadachesAir HungerChest PainPalpitationsSleepDizzinessOrthostatic IntoleranceExercise IntoleranceSweating
Pricing Example
RTHM Safety Assessment
Only charged if approved
Pharmacy Cost
90-day supply + shipping
Total for 90 days
With RTHM discount
RTHM Safety
Assessment Fee
Paid every 90 days
(only charged if approved)
$49
Pharmacy
Cost
90-day supply + shipping, paid to the pharmacy
$79
Estimated total
for 90 days
With RTHM discount
$128
Boost Energy and Reduce PEM
LDN acts as an immune modulator, shown to improve energy and mood, reduce inflammation, and reduce post-exertional malaise (PEM).
Pain Relief
LDN stimulates the release of endorphins and enkephalins, offering a natural path to relief for muscle and joint pain commonly experienced by Long COVID and ME/CFS patients.
Improve Sleep
LDN has been shown to reduce unrefreshing sleep and abnormal sleep patterns, allowing a better night’s rest.
Clearer Cognition
By reducing neuroinflammation, LDN protects the brain and supports clearer thinking helping you focus on what matters most.
Is LDN right for me?
LDN has been shown to help with:
- Fatigue and low energy
- Brain fog and impaired cognition
- Chronic pain and inflammation
- Post-exertional malaise
- GI issues such as diarrhea, bloating, etc.
- Skin conditions such as rashes, hives, and dry skin
Patients with Long COVID, ME/CFS, and other chronic conditions who experience these symptoms may benefit from LDN.
LDN is generally well-tolerated. Studies in Long COVID and ME/CFS suggest it is safe, with mild side effects such as vivid dreams, mild headaches, or occasional insomnia, which typically subside after 1-2 weeks of use.
Starting with a low dose and gradually increasing over time can reduce the risk of side effects. Taking LDN in the evening may also help minimize daytime discomfort.
- Individuals with known allergies to naltrexone or its ingredients
- Patients currently using opioids, as LDN may block their effects
- Patients who drink alcohol on a regular basis
- Patients with kidney, liver, or heart disease
Research Studies
A study from Stanford found that 54.2% of 59 Long COVID patients using LDN experienced an improvement in symptoms like fatigue, post-exertional malaise, unrefreshing sleep, and abnormal sleep patterns.
"Low-dose naltrexone use for the management of post-acute sequelae of COVID-19"
View Study52 patients with Long COVID were prescribed LDN and monitored for adverse effects. 70% of patients reported improvements in at least one category of energy, pain levels, concentration, sleep disturbances, ability to perform daily tasks, and recovery from COVID-19. The study also concluded that LDN was safe, with only 5.3% of participants stopping due to side effects.
"Safety and efficacy of low dose naltrexone in a long COVID cohort; an interventional pre-post study"
View Study36 Long COVID patients were given LDN and NAD+ patches for 12 weeks. The treatment boosted energy and reduced fatigue for approximately 50% of patients.
"Low-dose naltrexone and NAD+ for the treatment of patients with persistent fatigue symptoms after COVID-19"
View StudyA study of 108 patients taking amitriptyline, low-dose naltrexone, and physical therapy found that those taking LDN had a 5 times higher likelihood of improvement for both fatigue and pain.
"Low-dose naltrexone and NAD+ for the treatment of patients with persistent fatigue symptoms after COVID-19"
View StudyWhat People Are Saying About Their Experience with Low Dose Naltrexone
"It has without a doubt helped give me a significant bump in my baseline. I’ve been on it for several months now. I’m at 2mg and plan to bump up soon. As others mentioned, it does give you vivid dreams at times. Otherwise, I don’t notice any other side effects. I’ve been able to start hiking again wi..."
u/Responsible-Heat6842reddit.com
"...joined a triple therapy trial. <The triple therapy got me to> a 6-7/10 <but> my blood work wasn’t changing. I spoke to my other doctor about LDN and gave that a 6 month trial. That slowly got me back to a 10/10."
u/KentuckyFriedSoyreddit.com
"I am pretty much back to normal ... ldn helped me so much!! I do everything I used to do, however just a little bit more easy to tire out! A very far cry from when I was bed bound for 3 months. I owe my life to ldn!"
u/Good_Pie2522reddit.com
"57% of patients reported improvements on LDN."
Anonymousstuffthatworks.health