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Guanfacine
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Guanfacine

Get clinician-approved Guanfacine for brain fog and cognitive dysfunction.

ME/CFSLong COVIDMCAS
Brain FogMemoryCognitive Clarity

Pricing Example

RTHM Safety Assessment

Only charged if approved

$59

Pharmacy Cost

90-day supply + shipping

$15

Total for 90 days

With RTHM discount

$74

RTHM Safety
Assessment Fee

Paid every 90 days
(only charged if approved)

$59

Pharmacy
Cost

90-day supply + shipping, paid to the pharmacy

$15

Estimated total
for 90 days

With RTHM discount

$74

Clearer Cognition

Guanfacine acts on the prefrontal cortex, improving memory, attention, and executive functioning to help clear brain fog and restore mental clarity.

Improved Focus

By strengthening neural connections, guanfacine helps maintain sustained attention and reduces distractibility, making daily tasks more manageable.

Blood Pressure Control

Guanfacine helps stabilize blood pressure by reducing sympathetic nervous system activity, beneficial for those with dysautonomia-related hypertension.

Is Guanfacine right for me?

Guanfacine is particularly effective for:

  • Cognitive dysfunction (brain fog)
  • Forgetfulness and loss of words
  • Difficulty following conversations or completing tasks
  • Inability to concentrate
  • Hypertension

Patients with Long COVID, ME/CFS, or dysautonomia experiencing these symptoms may benefit from guanfacine.

Guanfacine is generally safe and well-tolerated, though mild side effects such as drowsiness or dizziness may occur. Patients with certain cardiac, kidney, or liver conditions should consult their healthcare provider before use.

Guanfacine may not be suitable for individuals with:

  • Structural cardiac abnormalities
  • History of bradycardia (slow heart rate)
  • Hypotension (low blood pressure)
  • Severe kidney or liver disease
  • Depression or stroke history

What Does the Research Say?

Guanfacine's action on alpha-2A adrenergic receptors in the prefrontal cortex supports attention, working memory, and impulse control. Its promising off-label use includes conditions such as PTSD, traumatic brain injury, ME/CFS, and Long COVID.

"Guanfacine's mechanism of action in treating prefrontal cortical disorders: Successful translation across species"

Guanfacine has shown potential to alleviate cognitive dysfunction by improving blood flow, modulating brain activity, and addressing the physical and mental fatigue often associated with complex illnesses.

"Guanfacine"

A novel treatment using guanfacine combined with N-acetylcysteine (GXN) was developed for ME/CFS brain fog. The three-patient case report indicated improvement in all participants with good tolerability.

"Guanfacine Plus N-Acetylcysteine for the Treatment of Cognitive Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Open-Label, Proof of Concept Trial (GXN in ME/CFS)"

Research Studies

Guanfacine's action on alpha-2A adrenergic receptors in the prefrontal cortex supports attention, working memory, and impulse control. Its promising off-label use includes conditions such as PTSD, traumatic brain injury, ME/CFS, and Long COVID.

"Guanfacine's mechanism of action in treating prefrontal cortical disorders: Successful translation across species"

View Study

Guanfacine has shown potential to alleviate cognitive dysfunction by improving blood flow, modulating brain activity, and addressing the physical and mental fatigue often associated with complex illnesses.

"Guanfacine"

View Study

A novel treatment using guanfacine combined with N-acetylcysteine (GXN) was developed for ME/CFS brain fog. The three-patient case report indicated improvement in all participants with good tolerability.

"Guanfacine Plus N-Acetylcysteine for the Treatment of Cognitive Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): An Open-Label, Proof of Concept Trial (GXN in ME/CFS)"

View Study

What People Are Saying About Their Experience with Guanfacine

"I was able to go back to school, work full time. I didn't crash, didn't have PEM. After getting to 1mg I had energy and mental stamina that allowed me to use my brain for more than an hour a day!"

u/No_Understanding9301reddit.com

"Brain fog improved from 4 to 7. I never thought my brain fog would improve. All because of guanfacine."

u/GlitteringAutistreddit.com

"I had moderate cfs/me with moderate brain fog… once I changed the dose, the brain fog went away completely!"

u/ErmintrudeFanshawreddit.com